ABSTRACT
Diabetes mellitus and hyperlipidemia both are independent risk factors for coronary heart disease, which is a major killer world wide. This study explains the effect of metformin [anti-diabetic drug] on lipid profile in rats. Thirty rats were allocated randomly into 3 groups each group included 10 rats. One group was put on normal chow diet for 16 W Ks and served as normal control group. The other 2 groups were given high cholesterol diet for 3 weeks. The blood samples were collected from these 3 groups before commencing treatment. Serum lipid profile namely T.G, TC, LDL, VLDL and HDL were measured. The result revealed that all 2 groups revert to hyperlipidimic condition. One of the two group received distilled water and served as hyperlipidimic control. The 2[nd] group received metformin at the same time the two groups kept on cholesterol rich diet for another 8 weeks. The serum lipid value were checked again after 8. weeks of treatment. In concerning triglyeeride metfoormin caused highly significant reduction in its serum level [P<0.01], and it caused significant reduction of total cholesterol [P<0.05] as well as metformine induced highly significant reduction in value of LDL, VLDL, but it increased significantly the level of serum HDL-cholesterol [P<0.01]